Study of the Antibiotic Resistance Patterns of Urinary Tract Infections in Hospitalized Children in Mazandaran

Background: Identifying antibiotic resistance in uropathogenic pathogens is essential to avoid treatment errors and minimize treatment costs. Despite the clinical significance of Urinary tract infections (UTIs) in children, limited data are available on the antimicrobial resistance patterns of the causative pathogens, highlighting the need for continuous surveillance. Our aim was to determine the pattern of drug resistance in strains isolated from children with UTI.Methods: This retrospective cross-sectional study was conducted from ۲۰۲۱ to ۲۰۲۳ at Bo Ali Sina Hospital in Sari, Iran. A total of ۱۵۰۲ positive urine culture samples from hospitalized children were included. Antimicrobial susceptibility testing was performed using the disk diffusion method, following Clinical and Laboratory Standards Institute (CLSI) guidelines Data analysis was carried out using Statistical Package for the Social Sciences (SPSS) software.Results: Of the ۱۵۰۲ cases, ۶۸.۸% were female. The most frequently isolated pathogen was Escherichia coli (۵۴.۸%), followed by Pseudomonas aeruginosa (۳.۳%) and Klebsiella spp. (۳.۱%). Among gram-positive bacteria, Staphylococcus epidermidis (۹.۰%) was the most prevalent. The highest susceptibility rates were observed for amikacin across E. coli, Klebsiella, and Pseudomonas isolates.Conclusions: Based on local susceptibility patterns, antibiotics such as amikacin, nitrofurantoin, gentamicin, imipenem, ceftazidime, and ceftriaxone may be considered for empirical treatment of complicated UTIs in hospitalized children to improve their care. However, whenever possible, narrow-spectrum antibiotics should be prioritized. Appropriate antibiotic selection must rely on microbial identification and resistance profiling.

کلیدواژه ها:

Antibiotic resistance ، Urinary tract infection ، uropathogenic bacteria