Oxybromination of styrene derivatives: Direct Access to phenacyl bromides

Phenacyl bromides have long served as important building blocks in chemical synthesis, particularly in the preparation of heterocyclic compounds owing to their two contiguous electrophilic centers. Consequently, tremendous efforts have been devoted to the development of efficient synthetic methodologies to this specific class of carbonyl compounds. The direct vicinal oxybromination of widely available styrene derivatives is one of the most efficient procedure for preparation of the titled compounds, benefiting high step, atom and pot economy. In this Mini-Review we discuss some of the most representative and interesting recent reports on the synthesis of phenacyl bromides through the direct oxybromination of respective styrenes with an emphasis on the reaction mechanisms.

کلیدواژه ها:

Difunctionalization ، oxybromination ، phenacyl bromides ، Styrenes ، olefinic double bonds