Preparation, characterization, and in vitro performance evaluation of polymeric scaffolds containing sodium alginate microspheres with methotrexate for controlled drug delivery

This study explores the development and characterization of polymeric scaffolds containing sodium alginate microspheres loaded with methotrexate for controlled drug delivery. We fabricated scaffolds using hexamethylene diisocyanate and polyelectrolyte, incorporating drug-loaded microspheres, scaffolds were thoroughly characterized using various analytical techniques, including FTIR, XRD and SEM, drug release kinetics were evaluated under physiological conditions, demonstrating sustained release profiles over ۱۵۰ hours, examinations of void spaces unveiled highly permeable structures conducive to cellular penetration and nutrient circulation. Decomposition patterns were evaluated in oxidizing and enzymatic settings, demonstrating steady disintegration across multiple weeks. Our discoveries indicate that these frameworks show potential for utilization in pharmaceutical administration and biological tissue construction, providing adjustable characteristics and regulated discharge abilities.

کلیدواژه ها:

Polymeric scaffolds ، Nanoparticles ، Drug delivery systems ، Controlled release ، degradation ، porosity