Factors Associated with In-Hospital Mortality in Adult Patients with Community-Acquired Staphylococcus aureus Bacteremia: A Cross-Sectional Study

Background & Objective: Community-acquired Staphylococcus aureus bacteremia (CA-SAB) is associated with substantial morbidity, mortality, and healthcare costs. This study aimed to identify clinical and laboratory factors associated with in-hospital mortality among patients with CA-SAB.Methods: This retrospective cross-sectional study was conducted at a tertiary referral hospital in Tehran, Iran. Adult patients with positive blood cultures for S. aureus who met CA-SAB criteria were included. Demographic, clinical, and laboratory data were collected from medical records. The primary outcome was in-hospital mortality. Univariate and multivariate logistic regression analyses were performed to assess associations with mortality.Results: A total of ۱۱۴ patients with CA-SAB were included. No significant association was observed between underlying comorbidities and mortality. Although methicillin-resistant S. aureus (MRSA) infection was associated with a higher mortality rate, this difference was not statistically significant (P = .۳۲). Multivariate analysis revealed that older age (odds ratio [OR], ۱.۰۵۳; ۹۵% CI, ۱.۰۱۲–۱.۰۹۵; P = .۰۱), elevated C-reactive protein (CRP) levels (OR, ۱.۰۱۶; ۹۵% CI, ۱.۰۰۵–۱.۰۲۸; P < .۰۱), and lower serum albumin levels (OR, ۰.۲۴۹; ۹۵% CI, ۰.۰۹۷–۰.۶۴۲; P < .۰۱) were independently associated with in-hospital mortality.Conclusion: Although age was not significant in univariate analysis, it emerged as a significant predictor after adjustment for other variables. Routine laboratory parameters such as CRP and albumin may serve as valuable prognostic indicators. Early identification of high-risk patients using these markers could inform timely interventions and improve outcomes in CA-SAB.

کلیدواژه ها:

Staphylococcus aureus ، bacteremia ، Mortality ، Community-Acquired Infections ، methicillin resistance