SYNERGISTIC THERAPEUTIC EFFECT OF THE VOLATILE OILS OF RHIZOMATOUS PLANTS ON SELECTED ADVANTAGEOUS PATHOGENS

In response to the escalating global drug resistance crisis, this study explores the potential of ginger (Zingiber officinale) and turmeric (Curcuma longa) volatile oils as alternative therapeutic agents individually and in combination. These oils were extracted using hydro-distillation and screened for their antibacterial potential against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia using the Agar well diffusion method. Antioxidant activity of the oils was also explored using DPPH and FRAP. The synergistic antimicrobial effects of the combined volatile oils were evaluated, comparing their ability with conventional antibiotics. The result revealed that the combined oils demonstrated better antimicrobial activity (ZI: ۱۸ mm to ۲۲ mm) than the individual oils (Ginger: ZI: ۱۳ mm to ۱۹ mm, Turmeric: ۱۷ mm to ۱۹ mm) against the bacteria screened. This activity of the combined oils (ZI: ۱۸ mm to ۲۲ mm) was comparable to that of the standard antibiotics: (Gentamycin, ZI: ۲۱ mm to ۲۲ mm). DPPH assay, revealed a value of ۵۲.۲۲ ± ۲.۳۰ μg/mL for the ginger extract and ۴۴.۲۲ ± ۲.۳۲ μg/mL for the Turmeric while FRAP assay revealed a value of ۶.۲۲ ± ۰.۰۴ μg/g, for ginger and ۴.۱۰ ± ۰.۰۴ μg/g for turmeric. Conclusively, the exploration of volatile oils from ginger and turmeric presents them as viable components in drug formulations for the fight against antimicrobial resistance due to their comparable activity to that of conventional antibiotics, especially in their combined form.

کلیدواژه ها:

Multidrug resistance ، Volatile oils ، Ginger ، Turmeric ، Synergy