Greener Alternative in Organic Synthesis: Aqueous Knoevenagel Condensation Reaction Catalysed by [Bmim][OAc] Ionic Liquid with Antimicrobial Evaluation

The Knoevenagel condensation of malononitrile or ethylcyanoacetate with different aldehydes, using ۱-butyl-۳-methylimidazolium acetate [Bmim][OAc] in an aqueous medium, was successfully done. This proposed approach offers several advantages, such as economy, short reaction time, eco-friendly and environmentally benign reaction medium, simple workup, recyclability of the ionic liquid, accelerated reaction rate, and high yields (۹۰-۹۷%). The resulting Knoevenagel adducts (۳c-f, ۳l-q) were further evaluated for their antimicrobial activity.

کلیدواژه ها:

Knoevenagel condensation ، greener alternative ، Ionic Liquids ، Recyclability ، Antimicrobial