Sodium isopropyl xanthate as efficient organic probe toward photochemical recognition of taurine biomarker in human urine

Taurine is a natural amino sulfonic acid that does not form part of proteins. The absence of taurine in cells can lead to serious diseases, sparking interest in its potential therapeutic use. Developed methods to measure taurine levels have limitation such as complexity, high equipment requirements, significant costs, and long research times, presenting technological challenges that need to be addressed. In addition, existing taurine analysis methods face challenges related to low sensitivity, limited selectivity, and complex procedures. This study for the first time is centered on the utilization of sodium isopropyl xanthate (SIPX) for the identification of taurine biomarkers by optical sensing technology. The swift and accurate assessment of taurine biomarker levels in human biofluids using UV-visible spectrophotometry to open a new horizon in enabling the early diagnosis of several significant pathologies and diseases. As part of this research, a novel photosensor has been proposed for the detection of taurine in human urine samples, utilizing SIPX as an optical nanoprobe. The interaction between the taurine biomarker molecule and SIPX results in a substantial change in the absorption spectrum, enabling swift, dependable, and timely measurements with detection capabilities ranging from ۱۰ μM to ۵۰ mM. This innovative chemosensor has proven to be effective in the analysis of taurine in human urine (with average SD of ۰.۰۶) through the application of sensor technology and has shown promise in the early diagnosis of neurodegenerative diseases in the brain. Therefore, this study stands as the first to specifically utilize SIPX for the detection of taurine in real samples. Furthermore, the designed optosensor suggest facilitates towards direct quantification of biomarkers in biological samples without the need for derivatization procedures or sample preparation.

کلیدواژه ها:

Taurine biomarker ، Photochemical sensor ، Sodium isopropyl xanthate ، neurodegenerative diseases ، Optical bioanalysis