Diabetic Ketoacidosis Before, During, and After The COVID-۱۹ Pandemic

Background: Diabetic ketoacidosis (DKA) can be the initial sign of type ۱ diabetes in children upon diagnosis. Some studies have examined the impact of the coronavirus disease ۲۰۱۹ (COVID-۱۹) pandemic on the incidence and severity of DKA in children. The aim of this study was to investigate the status of diabetic ketoacidosis before and during COVID-۱۹.Methods: This cross-sectional study was conducted at Akbar Pediatric Super-specialty Hospital in Mashhad and included one year before and one year after the start of the COVID-۱۹ pandemic. All children under ۱۸ years old admitted with a diagnosis of DKA based on the ۲۰۱۸ international society for pediatric and adolescent diabetes (ISPAD) protocol were included in the study. A checklist was completed for each patient, and the data was entered into SPSS software for analysis. A significance level of ۰.۰۵ was set for all inferential statistical tests.Results: A total of ۳۱۰ patients were included in the study, of which ۱۷۶ (۵۶.۸%) were male and the rest were female. In ۲۰۱۸, only ۳۳% of new cases were diabetic, while in ۲۰۲۰, this rate had reached ۵۷.۲% (p=۰.۰۰۶). ۱۸.۴% of patients during the COVID-۱۹ era had bicarbonate levels less than ۵ upon admission, whereas during the pre-COVID era, only ۵.۳% of patients had bicarbonate levels less than ۵. The rate of Intensive care unit (ICU) admission in ۲۰۲۰ was significantly higher than in ۲۰۱۸ (p=۰.۰۰۳), with ۱۵.۹% of patients being admitted to the ICU in ۲۰۲۰.Conclusion: Based on the results of our study, the rate of patients diagnosed with diabetes and diabetic ketoacidosis significantly increased during and after the COVID-۱۹ pandemic.

کلیدواژه ها:

Children ، COVID-۱۹ ، Diabetes ، Diabetic Ketoacidosis