Efficacy Comparison of Zea Mays and Tamsulosin in Alleviating Pain and Facilitating the Passage of Renal and Ureteral Stones Measuring ۴-۱۰ Millimeters

Introduction: Given the high incidence of urinary stones and their associated complications, along with the diuretic properties of Zea mays, this study aimed to assess the effectiveness of Zea mays in facilitating the passage of kidney and ureteral stones in comparison to tamsulosin.Methods: This randomized clinical trial involved ۸۰ participants aged over ۱۸ years with renal and ureteral stones ranging from ۴ to ۱۰ millimeters. After obtaining informed consent and ethical approval, participants were divided into two groups. In Group ۱, following ultrasonography to confirm stone presence, Zea mays sourced from Yasuj city was prepared, dried in the shade, and encapsulated. Participants were instructed to take one capsule every ۱۲ hours for two weeks. In Group ۲ (the control group), participants received one capsule of tamsulosin (۰.۴ mg) nightly for the same duration. After two weeks, follow-up visits were conducted, KUB sonography was performed to assess stone size and residual presence, and pain severity was evaluated using the Visual Analogue Scale (VAS). Data were analyzed using SPSS version ۲۱ and appropriate statistical tests.Results: No significant differences were found between the two groups concerning mean age (P-value=۰.۷۹۹), gender (P-value=۰.۵۵۹), mean stone size (P-value=۰.۰۹۵), number of stones (P-value=۰.۴۷۳), and pain levels (P-value=۰.۳۶۰). Within-group comparisons revealed a significant decrease in the number of stones (P-value=۰.۰۰۰), pain levels (P-value=۰.۰۵), and mean stone size (P-value=۰.۰۰۰) for both groups. Post-intervention efficacy indicated that in the tamsulosin group, ۱۷.۵% achieved complete stone passage and ۳۲.۵% had partial success. In contrast, the Zea mays group reported a ۲۵% complete response and a ۲۷.۵% relative response.Conclusion: The findings of this study indicate that both Zea mays and tamsulosin are effective in reducing the size and quantity of renal and ureteral stones, as well as alleviating pain during the expulsion process. However, no significant differences were observed between the two treatments.

کلیدواژه ها:

Urinary stone ، Zea Mays Tamsulosin ، treatment