Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial

Objective: This study aimed to evaluate Glasthma, a Persian medicine herbal formulation for its efficacy and safety in managing asthma symptoms and modulating intestinal permeability.Materials and Methods: Forty randomly assigned asthma patients received Glasthma syrup (n=۲۰) or a placebo (n=۲۰) twice daily for ۴ weeks. Respiratory symptoms, pulmonary function tests, and ۵-hour urine lactulose to mannitol ratio were assessed at baseline and after ۴ weeks.Results: Glasthma group exhibited significant improvements in clinical and paraclinical scores, including asthma control test (p<۰.۰۰۱), asthma control questionnaire ۷ (p<۰.۰۰۷), Forced Expiratory Volume in the First Second (p<۰.۰۰۱), and Maximal Mid-Expiratory Flow ۲۵-۷۵ (p<۰.۰۰۲) compared to the placebo group. Lactulose and mannitol levels significantly decreased in the Glasthma group (p<۰.۰۲۸ and p<۰.۰۰۰۰, respectively), with no significant changes in the ratio. No serious adverse effects were observed.Conclusion: These findings suggest that Glasthma formulation may effectively improve asthma symptoms and regulate the gut-lung axis.

کلیدواژه ها:

Asthma ، Intestinal permeability ، Traditional Persian medicine Phytotherapy