Protective effects of Elaeagnus angustifolia L. fruit extract on CCl۴-induced oxidative stress and inflammation in rats liver

Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl۴ damage.Materials and Methods: ۳۰ Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl۴ control, E. angustifolia extract pretreatment (۶۰۰ mg/kg), and silymarin pretreatment (۱۰۰ mg/kg). After ۱۴ days of oral administration of extracts, CCl۴ was injected intraperitoneally. The samples were collected ۴۸ hr later. Histological and biochemical analyses were then carried out.Results: CCl۴ injection caused significant (p<۰.۰۰۱) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E. angustifolia extract pre-treatment significantly (p<۰.۰۵) returned changes to the normal state.Conclusion: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl۴ in rats.

کلیدواژه ها:

Elaeagnus angustifolia L ، Carbon tetrachloride ، Liver damage ، Oxidative stress ، Antioxidant