Effects of Bisphenol A (BPA) in commercially important fish Common Carp (Cyprinus carpio) in Kerala

The study is on the toxic effects of Bisphenol A in Cyprinus carpio, an Indian freshwater fish, presumably highly nutritious in proteins, and one that finds extensive usage in aquaculture establishments. BPA ranks very high among dispersing contaminants in freshwater systems, chiefly wetlands; hence, pressing attention is warranted. Thereafter, a certain set of hematological, histological, and biochemical parameters had been observed on the seventh day following exposure to BPA at sub-lethal concentrations of ۰.۱, ۰.۲, and ۰.۵ mg/L. The amount of RBC showed a decreasing trend from ۲.۹۵×۱۰۶ to ۲.۳×۱۰۶ Cells/mm۳ in ۰.۵ mg/L dose. However, the hemoglobin concentration, an opposite trend was observed, from ۱۱.۲ g/dL in control to ۸.۵ g/dL concentration. An opposite trend was noticed in WBC counts that increased from ۹.۱×۱۰۳ to ۱۳.۴×۱۰۳ Cells/mm۳ at ۰.۵ mg/L, thus indicating hematological stress and activation of immune defense. Degeneration in testes and ovaries of fish, implicated through observed histological changes, further corroborates the estrogenic effect of BPA. This was accompanied by a reduction in antioxidant enzyme activities and an elevation in lipid peroxidation, a classical indicator of oxidative stress. Given such findings, the present study emphatically argues against BPA to reduce its effect on aquatic life, thereby affecting the environment and food safety.

کلیدواژه ها:

Bisphenol A (BPA) ، Cyprinus Carpio ، Hematological ، Histological ، Oxidative Stress