Polydopamine-Based Coatings Functionalized with SM-۷۳۳۸: Impact on Surface Properties and Antibacterial Performance

Polydopamine (PDA) is a versatile biopolymer widely utilized for surface modification and bioactive coatings due to its strong adhesion, hydrophilicity, and chemical flexibility. This study explores the incorporation of (۴R,۵S,۶S)-۳-[(۳S,۵S)-۵-(dimethylcarbamoyl)pyrrolidin-۳-yl] sulfanyl-۶-(۱-hydroxyethyl)-۴-methyl-۷-oxo-۱-azabicyclo[۳.۲.۰]hept-۲-ene-۲-carboxylic acid, a broad-spectrum ß-lactam antibiotic (meropenem), into PDA-based coatings to enhance their properties for biomedical applications. The effects of varying antibiotic concentrations on key coating characteristics, including hydrophilicity, thickness, and surface morphology, were systematically analyzed using water contact angle measurements, colorimetry, and field emission scanning electron microscopy (FESEM). The results demonstrate that increasing meropenem concentration enhances hydrophilicity and coating thickness, while also influencing the surface morphology by inducing changes in nanoparticle distribution. These findings highlight the potential of functionalized PDA coatings as a promising approach for preventing bacterial biofilm formation and improving surface properties in medical and biotechnological applications. Further studies are needed to comprehensively assess their long-term stability, antimicrobial performance, and biocompatibility across various real-world biomedical applications and environments.

کلیدواژه ها:

Polydopamine ، Hydrophilicity ، Biofilm prevention ، Surface modification