Metabolic syndrome in reproductive age: A cross-sectional study

Background: Obesity and metabolic syndrome (MetS), as components of excess body weight, have reached global epidemic levels. Objective: The study aimed to investigate the features of the MetS course in men and women of reproductive age. Materials and Methods: This cross-sectional study was conducted with ۱۴۰ participants aged between ۳۵ and ۴۹ yr at City Polyclinics No. ۱, ۳, and ۴, Aktobe, Kazakhstan from March ۲۰۱۶-۲۰۱۹. Participants were divided into ۲ subgroups based on diagnosis of MetS. The case group (with MetS), and the control group (without MetS) (n = ۷۰/each consisted of ۴۰ women and ۳۰ men). Anthropometric, instrumental, and laboratory methods were used to confirm the diagnosis of MetS and determine its features in both groups. Results: The results showed an increase in the uric acid level in the blood to ۴۳۱.۰۰ ± ۶۶.۳۷ μmol/L and ۵.۴۷ ± ۰.۹۰ mol/day in the urine. Dyslipidemia was also noted in the case group of individuals with high-density lipoprotein levels of ۱.۲۲ ± ۰.۲۷ mmol/L vs. ۱.۳۲ ± ۰.۴۷ mmol/L in the control group. The testosterone level was ۱۶.۴ ± ۳.۰۴ nmol/L in the case group and ۲۰.۳ ± ۵.۶ nmol/L in the control. The difference in testosterone level was found to be statistically significant (p ˂ ۰.۰۱). Conclusion: The analysis of sex hormone levels did not reveal any stable trends that could be considered diagnostic. That may indicate a correlation with the reproductive age characteristics of the examined individuals (men and women): significant differences between hormone levels were fixed in the case and control groups.

کلیدواژه ها:

Metabolic syndrome ، Abdominal obesity ، Dyslipidemia ، Insulin resistance ، Sex hormones. ، سندرم متابولیک ، چاقی شکمی ، اختلال چربی خون ، مقاومت به انسولین ، هورمون های جنسی.