Association of blood progesterone levels on trigger day and low oocyte retrieval in cases with polycystic ovary syndrome undergoing in-vitro fertilization: A prospective cohort study

Background: The number of follicles aspirated during intracytoplasmic sperm injection (ICSI)/in vitro fertilization (IVF) treatment does not always match the number of oocytes recovered. Objective: This study aimed to assess the oocyte retrieval rate (ORR) distribution data and investigate the risk factors for low ORR in polycystic ovary syndrome (PCOS) cases undergoing IVF/ICSI. Materials and Methods: This prospective cohort study was conducted on ۱۴۰ women aged between ۱۸ and ۴۰ yr with PCOS who were referred to Arash hospital in Tehran, Iran for ICSI/IVF treatment from March to November ۲۰۲۴. The ratio of obtained oocytes to follicles (≥ ۱۷ mm) on the trigger day was used to determine the OPR. ۱۴۰ women were split into ۲ groups: one with a low ORR and one with a normal ORR, each separated by one standard deviation from the ORR mean. Results: No significant difference was observed between the low and normal ORR groups for progesterone levels. A statistically significant difference was observed in terms of estradiol/follicle ratio above ۱۷, number of follicles above ۱۷, and number of retrieved eggs between the low and normal ORR groups. Logistic regression analysis showed that serum estradiol/follicle ratio (≥ ۱۷ mm) with (OR = ۰.۹۶, ۹۵% CI [۰.۹۴-۰.۹۸], p = ۰.۰۰۱) was a factor affecting low ORR. Conclusion: Low ORR, which results in fewer embryos and more cycle cancellations, may be caused by low progesterone levels on the trigger day, low estradiol levels/follicles (≥ ۱۷ mm), and the use of the progestin-primed regimen in PCOS cases.

کلیدواژه ها:

Fertilization in-vitro ، Oocyte ، Polycystic ovary syndrome ، Progesterone ، Estradiol. ، لقاح آزمایشگاهی ، تخمک ، سندرم تخمدان پلی کیستیک ، پروژسترون ، استرادیول.