Design and Dynamic Optimization of a Multilayer Piezoelectric as an External Ultrasonic Probe for Targeted Mechanical Stimulation in Tissue Regeneration

In recent years, piezoelectric materials have garnered significant attention for their advantageous properties in promoting angiogenesis and facilitating cellular growth within damaged tissues. A particularly promising application of these materials lies in the development of piezoelectric probes that can apply specific frequencies to stimulate tissue regeneration. This study presents the systematic design, simulation, and optimization of a multilayer piezoelectric polymer composite ultrasonic probe engineered for both tissue simulation and biomedical imaging. By systematically incorporating a piezoelectric layer for optimal energy conversion, an elastomeric layer to modulate vibration transmission, and a biopolymeric layer to facilitate seamless interaction with biological tissues, this research endeavors to produce a lightweight, mechanically stable, and dynamically optimized probe design. By conducting comprehensive simulations, including stress analysis and frequency optimization, this study demonstrates that the proposed multilayer configuration, comprising PVDF, elastomer, and biopolymer, not only ensures structural integrity and operational efficiency but also effectively delivers targeted mechanical stimulation to promote angiogenesis and cellular proliferation in damaged tissue. Comprehensive modal and Von Mises stress analyses were conducted to evaluate the design's dynamic performance and structural integrity. The optimization process resulted in eigenfrequencies ranging from ۲.۹ kHz to ۹.۸ kHz, which are ideal for effective tissue stimulation. Moreover, the stress distribution analysis confirmed low-stress concentrations throughout the probe’s structure, thereby ensuring operational safety. The effective modal mass was minimized to enhance the probe's lightweight and efficient design, establishing its potential for real-world biomedical applications. This study establishes a robust groundwork for the practical deployment of intelligent, adaptable ultrasonic probes in clinical and biomedical environments. Furthermore, it sets a definitive perspective for subsequent experimental validation and continued advancement of the design, with a focus on exploring complex Multiphysics interactions within the probe system for enhanced functionality.

کلیدواژه ها:

Piezoelectric ، tissue repair ، PVDF ، PVDF-PTRFE ، ultrasonic