BCL۲ Expression in the Brains of Diabetic Rats Treated with Ginger

Objective: Diabetes is one of the most common high-risk diseases which causes many side effects in most body systems such as the nervous system. The medicinal plants, has been suggested to reduce the side effects of this diseases. In this experimental study, we examined the effect of ginger on BCL۲ gene expression in the hippocampus of diabetic rats. Materials and Methods: In this experimental study, we used ۶۰ Wistar rats (۲۰۰gr). We separated the rats into one healthy group and four groups of diabetics which after seven days of diabetes induction via Streptozotocin (۶۰ mg/kg), received different mixture of insulin and ginger for ۶ weeks. ۲۴ hours after the last injection, brains of rats were removed and the hippocampus region was studied histologically and the BCL۲ gene expression examined by Real-time PCR. Results: According to the results, the blood glucose level in the ginger treated group (۱۸۳.۱۷) decreased significantly compared to the diabetic control group (۲۳۲.۵) (P˂ ۰.۰۱). In the expression of BCL۲ gene, there was not any significant difference among the groups. In the histological examination of the hippocampus CA۱ region, the ginger-insulin treated group had less pyknotic neurons than the diabetic control group. Conclusion: According to results, the ginger, in addition to glycaemia reduction and despite any significant change in BCL۲ gene expression, can cause the safe neurons with the bright nucleus and clear nucleolus remain in the treated group, which can indicate that maybe ginger could inhibit the creation of apoptosis.

کلیدواژه ها:

Apoptosis ، Glycaemia ، Ginger ، Hippocampus