Evaluation of QTc Interval Pre- and Post-Albumin Administration in Pediatric Nephrotic Syndrome Patients with Hypocalcemia

Background: Nephrotic syndrome (NS) in children is characterized by heavy proteinuria, hypoalbuminemia, and edema. Hypocalcemia, commonly resulting from urinary loss of albumin-bound calcium, can prolong the QT interval, increasing the risk of ventricular arrhythmias. This study aimed to evaluate the effect of albumin administration on the corrected QT (QTc) interval in pediatric NS patientsMethods: A cross-sectional study was conducted on ۲۰ children with NS and hypoalbuminemia who received albumin infusions. Baseline electrocardiograms (ECGs) and serum parameters, including albumin and electrolyte levels, were recorded before and after albumin infusion. QTc intervals were calculated using Bazett’s formula. The Wilcoxon signed-rank test was used to assess changes in QTc before and after infusion.Results: The study included ۲۰ children with NS (۱۵ males, ۵ females; mean age ۶ ± ۴ years). The mean serum albumin level was ۲ ± ۰ g/dL, indicating significant hypoalbuminemia. Hypocalcemia was present in ۷۹% of patients and was associated with higher QTc intervals. The mean QTc decreased from ۴۱۱ ± ۴۵ ms pre-infusion to ۴۰۱ ± ۴۴ ms post-infusion, showing a statistically significant reduction (p < ۰.۰۰۱), particularly in patients with hypocalcemia.Conclusion: Albumin administration significantly reduces QTc intervals in children with NS, especially those with hypocalcemia, potentially lowering the risk of arrhythmias. Further research is warranted to evaluate the long-term cardiac effects of albumin therapy in this population.

کلیدواژه ها:

Hypocalcemia ، Nephrotic syndrome ، Pediatrics ، QTC interval