The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients with Congestive Heart Failure: A Systematic Review and Meta-Analysis Study

Background & Objective: High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a critical biomarker in cardiovascular diseases, particularly in congestive heart failure (CHF). This systematic review and meta-analysis aimed to assess the association between hs-cTnT levels and clinical outcomes in patients with CHF.Methods: A comprehensive literature search was performed across multiple databases to identify studies evaluating the relationship between hs-cTnT levels and clinical outcomes in CHF. Eligible studies reported hazard ratios (HRs) or odds ratios (ORs) for all-cause mortality, cardiovascular mortality, or cardiovascular hospitalization.Results: Elevated hs-cTnT levels were significantly associated with adverse outcomes. The pooled HR and OR for all-cause mortality were ۱.۷۰ (۹۵% CI, ۱.۴۹–۱.۹۴) and ۶.۱۹ (۹۵% CI, ۳.۸۸–۹.۸۶), respectively. For cardiovascular mortality, the pooled HR was ۱.۵۹ (۹۵% CI, ۱.۳۸–۱.۸۳) and the pooled OR was ۶.۸۷ (۹۵% CI, ۳.۹۳–۱۲.۰۱). For cardiovascular hospitalization, the pooled HR was ۱.۵۶ (۹۵% CI, ۱.۴۲–۱.۷۰) and the pooled OR was ۴.۳۲ (۹۵% CI, ۲.۲۲–۸.۳۹).Conclusion: Elevated hs-cTnT levels are strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalization in patients with CHF. These findings highlight the prognostic value of hs-cTnT in the clinical management of heart failure.

کلیدواژه ها:

High-Sensitivity Troponin T ، Congestive heart failure ، Mortality ، hospitalization ، Clinical outcomes