The Effect of High-Intensity Interval Training With High-Fat Diet on The Regulation of The Inflammasome Complex in The Adipose Tissue of Male Wistar Rats

Obesity is one of the main causes of systemic inflammation in the body, which can cause other metabolic diseases. It is believed that sports activity can reduce obesity and inflammation caused by it. Therefore, the present study was conducted to investigate the effect of a period of high-intensity interval training with the consumption of high fat food on the regulation of the inflammasome complex in the adipose tissue of male Wistar rats. Materials and methods: In the present experimental study; ۲۴ male Wistar rats (age: six weeks); were divided into four groups: control (C), exercise (HIIT), high-fat diet (HFD), high-fat diet + exercise (HFD + HIIT). Diet and exercise interventions started at the same time and continued for ۱۰ weeks. Weight, BMI, serum lipid profile, and also the expression of NLRP۳ and IL-۱ẞ in visceral adipose tissue were measured. To determine changes between groups, one-way ANOVA and Tukey's post hoc test were used, and an independent t-test was used to determine the intensity of the effect size using SPSS۲۷ software (P<۰.۰۵). Results: Significant weight reduction (P=۰.۰۰۹), NLRP۳ expression (P=۰.۰۰۱), IL-۱۳ (P=۰.۰۰۱), and LDL and cholesterol levels (P=۰.۰۰۱) in the HFD+HIIT group compared to HFD were seen. Also, a significant increase in HDL and HDL/LDL was observed in the HFD+HIIT group compared to the HFD group (P=۰.۰۰۱). Conclusion: The