Enhancing restaging of a colorectal cancer patient: The advantage of [۹۹mTc]Tc-FAPI-۴۶ over conventional CT in detecting metastases

We report the case of a ۷۳-year-old male with a history of colon adenocarcinoma, diagnosed ۱۸ months prior. The patient underwent total colectomy and chemoradiotherapy ۱۵ months previously. Due to recurrent abdominal pain, a metastatic workup was conducted utilizing both contrast-enhanced CT scan and [۹۹mTc]Tc-FAPI-۴۶ SPECT/CT. The latter imaging identified three metastatic lesions, while the contrast-enhanced CT scan detected only one peritoneal deposit. The two remaining metastases were small and hidden between the bowel loops and were not obvious on the conventional CT images. This case demonstrates that [۹۹mTc]Tc-FAPI-۴۶ SPECT/CT offers enhanced sensitivity for the detection of metastatic lesions in the post-operative patients with colorectal cancer when compared to conventional contrast-enhanced CT scans. The use of [۹۹mTc]Tc-FAPI-۴۶ SPECT/CT has the potential to significantly enhance the sensitivity of metastases detection, thereby influencing clinical decision-making in patients with colorectal cancer.

کلیدواژه ها:

[۹۹mTc]Tc-FAPI ، SPECT/CT ، Contrast-enhanced CT ، Colorectal cancer ، Metastasis