Synthesis, Characterization, Antibacterial, and Inhibitory Activity of Cu(II)-EDTA Complex Against DENV-۲

Cu(II)-EDTA has been successfully synthesized using the solvothermal method and testes for antibacterial and anti-DENV۲ activities. Cu(II)-EDTA complex compounds are characterized by FTIR, UV-Vis, SEM, DSC, and PSA. The Cu-(II)-EDTA particle size was ۶.۹۱ nm with a PDI value of ۰.۰۸۰۸. the morphology of a crystal is a cube with a rough and irregular surface. The Cu(II)-EDTA complex demonstrated notable activity against gram-negative bacteria (Escherichia coli) and gram-positive bacteria (Staphylococcus aureus) with a zone of ۸.۸۳ ± ۱.۳۰ and ۱۲.۰۶ ± ۱.۲۶ mm at a concentration of ۲۵۰ mg/mL, respectively. Furthermore, cytotoxicity against Vero cell and anti-DENV۲ was observed with a CC۵۰ of ۴۱۵.۴۴ μg/mL and IC۵۰ of ۲۷۰.۹۸ μg/mL, suggesting their potential use as antibacterial against E. coli, S. aureus, and anti-DENV۲ agent.

کلیدواژه ها:

Cu(II)-EDTA ، Characterization ، E. coli ، S. aureus: Anti-DENV