Halosulfenylation of indoles: A review

The direct vicinal difunctionalization of heteroarenes has emerged as a powerful approach for rapid increase of molecular complexity in one synthetic step. In this context, halosulfenylation of indoles have recently observed considerable attention not only because of diverse biological activities of thioindoles, but also because of usefulness of carbon-halogen bonds for further synthetic transformations using different convenient reactions. In this Focus-Review, we summarize the available literature on this novel and rapidly growing research topic by hoping that it will serve to stimulate further research and thinking in this area.

کلیدواژه ها:

vicinal difunctionalization ، halosulfenylation ، Indoles ، thioindoles ، ۲-halo-۳-arylthioindoles ، C-S bond formation