The development of chitosan-salicylic acid crosslinked tripolyphosphate as a pH-sensitive nanocarrier for doxorubicin controlled release

Researchers have focused a lot of attention in recent years on using chitosan-based nanocarriers for drug-controlled release to cancer cells. Therefore, in this work, tripolyphosphate (TPP)-crosslinked CS-salicylic acid nanocarriers (CS@SA-DOX-TPP) were created pH-sensitive nanocarriers for the controlled release of doxorubicin (DOX) to the cancer cell. The effective synthesis of nanocarriers is evaluated and validated through various techniques, including FT-IR, XRD, FE-SEM, TEM, DLS, and Zeta potential analysis. The encapsulation efficiency (EE %) of the CS@SA-DOX-TPP was found to be ۸۴.۹ %, respectively. The in vitro drug release analysis confirmed the controlled and pH-sensitive nature of drug release from the synthesized CS@SA-DOX-TPP. The Kosmeyer-Peppas model with Fickian diffusion effectively characterized the release mechanism of DOX. Furthermore, the biocompatibility and safety of the synthesized CS@SA-TPP and greater cytotoxic effects of CS@SA-DOX-TPP against MCF-۷ breast cancer cells confirms by cellular cytotoxicity assy. The results obtained indicate that the developed CS@SA-DOX-TPP may serve as a biocompatible drug delivery system for cancer treatment.

کلیدواژه ها:

Chitosan ، doxorubicin ، Nanocarrier ، pH-sensitive ، Tripolyphosphate ، Controlled release