Evaluation of diagnostic value of platelet parameters in patients with coronary artery disease (CAD) and acute myocardial infarction referred to Imam Ali Hospital in ۲۰۲۲

Coronary artery disease (CAD) is one of the leading causes of death worldwide. Early identification of factors associated with this disease can play a significant role in its prevention and management. Platelet indices have proposed as potential markers in predicting and assessing CAD. This study aimed to investigate the relationship between these indices and CAD in patients visiting Imam Ali (AS) Hospital in Kermanshah. This cross-sectional study conducted on patients with coronary artery disease (CAD) visiting Imam Ali (AS) Hospital in Kermanshah. Patients categorized into the intervention group, while healthy individuals placed in the control group. Demographic information, clinical findings, laboratory results, and platelet indices collected using a checklist. Data were analyzed using SPSS version ۲۶, with independent t-tests and one-way ANOVA used to compare the groups. The mean age of patients with CAD was ۶۱.۲۴±۱۱.۱۳ years, while the mean age of healthy individuals was ۵۶.۳۶ ± ۱۸.۸۶ years. The percentage of males in the patient group was ۷۹.۳۳%, and in the healthy group, it was ۵۶%. The gender distribution between the two groups was statistically significant (P-value=۰.۰۰۱). The mean platelet distribution width (PDW) was significantly higher in healthy individuals compared to CAD patients (P=۰.۰۰۱), while no significant differences were found in mean platelet volume (MPV) and platelet large cell ratio (P-LCR) between the groups. Logistic regression analysis showed that with each one-unit increase in PDW, the likelihood of having CAD decreased (OR=۰.۳۰, P=۰.۰۰۱). The findings of this study suggest that the mean PDW in healthy individuals is significantly higher than in patients with CAD, to further assess this relationship, conducting prospective studies with larger sample sizes recommended

کلیدواژه ها:

Coronary Artery Disease ، Platelet indices ، PDW ، MPV ، P-LCR ، Troponin