Evaluation Of L-Theanine`S Effect On Hepatic Enzyme Profiles In Cholestatic Rats

سال انتشار: 1404
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 521

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شناسه ملی سند علمی:

MSHCONG09_034

تاریخ نمایه سازی: 13 تیر 1404

چکیده مقاله:

Cholestatic liver disease is a leading cause of global morbidity and mortality. The experimental model of bile duct ligation (BDL) is commonly applied to simulate cholestasis in laboratory studies. L-Theanine, classified as a non-protein amino acid, is predominantly synthesized within the roots of the green tea plant, Camellia sinensis, and subsequently concentrates within its foliage. This study aimed to evaluate L-Theanine`s effect on hepatic enzyme profiles in cholestatic rats. Forty adult male Wistar rats were randomly allocated into eight experimental groups of five animals each, comprising: ۱) Intact, ۲) BDL, ۳-۵) Intact + L-Theanine, ۶-۸) BDL + L-Theanine. Rats were orally administered L-Theanine solution (۱۰۰, ۲۰۰ or ۴۰۰ mg/kg body weight sequentially) via intra-gastric gavage (daily) for a ۳۰-day continuous period. At the end of this period, cardiac puncture was performed, followed by biochemical analysis. Our results demonstrated that BDL remarkably increased the plasma concentration of Alanine aminotransferase, Aspartate aminotransferase, Alkaline phosphatase, Gamma-glutamyl transferase, as well as total bilirubin levels. L-Theanine treatment in BDL rats markedly attenuated these biochemical changes. The greatest decrease in the concentration of these enzymes and total bilirubin was achieved with a dose of ۴۰۰ mg/kg body weight. These results indicate that L-Theanine can ameliorate cholestatic liver injury and hepatocellular damage caused by sequestered bile acids.

نویسندگان

Mobina Daneshnia

Graduated from Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

Pejman Mortazavi

Department of Pathology, Faculty of specialized Veterinary, Science and Research Branch, Islamic Azad University, Tehran, Iran

Mahsa Ale-Ebrahim

Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Razieh Hosseini

Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran