Electrospun PLGA/HPMC/ZnO Nanocomposite Dressings For Clinical Wound Management: Enhanced Hydrophilicity And Broad-Spectrum Antibacterial Efficacy

Electrospun antibacterial nanofiber wound dressings have emerged as an advanced solution for wound healing due to their unique characteristics, such as high specific surface area, optimal porosity, and the ability to mimic the extracellular matrix. This study focuses on the development of a novel wound dressing based on poly (lactic-co-glycolic acid) (PLGA), hydroxypropyl methylcellulose (HPMC), and zinc oxide nanoparticles (ZnO) via electrospinning. The fabricated nanofibers were evaluated for hydrophilicity, morphological properties, and antibacterial activity. The incorporation of HPMC into the PLGA matrix significantly enhanced hydrophilicity (reducing the water contact angle from ۱۱۰° to ۳۰°), while ZnO nanoparticles demonstrated strong antibacterial efficacy against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli), with inhibition zones of ۱۶ mm and ۱۸ mm, respectively. SEM and optical microscopy images confirmed the uniform dispersion of ZnO nanoparticles within the defect-free nanofiber structure. The PLGA/HPMC/ZnO composite achieved ۳۵۰% water absorption after ۶۰ minutes, providing an ideal moist microenvironment for wound healing. These findings suggest that the optimized PLGA/HPMC/ZnO composite, with its multifunctional properties, represents a promising candidate for clinical wound dressing applications.

کلیدواژه ها:

Antibacterial Wound Dressing ، Tissue Engineering ، Electrospinning