Association between Systemic Immune-Inflammation Index, Body Composition, and Mortality among Older Adults

Introduction: Chronic inflammation in older adults is associated with various age-related diseases and may contribute to functional decline and reduced quality of life. An imbalance in body composition, characterized by excess fat and inadequate muscle mass levels, has been identified as an underlying cause of inflammation. Numerous prognostic factors, such as indicators, have been employed to measure inflammation. The Systemic Immune-Inflammation Index (SII) is a reliable indicator of inflammation that correlates with mortality in numerous investigations substantially. This paper aims to examine the relationship between body composition, mortality, and SII. Methods: This cross-sectional study was conducted on ۶۰ years old or older adults using the Neyshabur Longitudinal Study on Ageing (NeLSA) data. SII scores were calculated using data from individual blood bank records. Data analysis involved analytical techniques such as correlation coefficient, logistic regression, and linear regression. Results: A total of ۳,۵۳۴ individuals participated, of whom ۱,۸۵۸ were male. The median age of participants was ۶۵.۷۱. The study revealed a significant association between the percentage of body fat and SII (p<۰.۰۰۱). The overall mortality rate was ۰.۹۳ in ۱۰۰۰. Mortality was linked to SII after adjusting for confounding variables (OR=۱.۰۰۱, ۹۵% CI=۱.۰۰۰ to ۱.۰۰۲, P=۰.۰۴۷). Conclusion: SII only correlated with blood pressure and body fat. A weak correlation was observed between SII and hs-CRP, which was associated with overall mortality in older adults.

کلیدواژه ها:

Elderly ، Inflammation ، Body composition ، Systemic Immune-Inflammation Index