An efficient one-pot three-component synthesis of α-amino nitriles via Strecker reaction catalyzed by lanthanium(III) chloride

One-pot multi-component condensation reactions are important and attractive due to the formation of multi-bonds in one pot, high atom economy, mild and simplified conditions and environmentally benign friendliness. Strecker reaction as the first multi- component reaction (MCR), which was discovered in 1850, represented one of the most important reactions, especially from the life science viewpoint (Strecker, 1850). In this reaction three components including a carbonyl compound (generally an aldehyde), an amine and either alkaline metal cyanide or hydrogen cyanide couple together and produce α-amino nitriles. A convenient and efficient one-pot method for the synthesis of a variety of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (TMSCN) in the presence of a catalytic amount of LaCl3at room temperature in acetonitrile (MeCN) is described. The significant features of this method are simple work-up procedure, inexpensive and non-toxic catalyst, shorter reaction times and excellent product yields. The catalyst LaCl3can be reused. The reusability of the catalyst has been studied for the synthesis of various amino nitriles.

کلیدواژه ها:

LaCl3 ، Amino nitriles ، One-pot synthesis ، Strecker reaction