Exploring the Versatile Pharmacological Potential of Indole Derivatives: A Comprehensive Review

Alkaloids, pigments, proteins, amino acids, and other substances contain a chemical structure called indole. Tryptophan-derived tryptamine alkaloids, which significantly impact neurotransmitters like melatonin and serotonin, require substituted indoles as necessary constituents. Several widely used drugs, including those for HIV, cancer, erectile dysfunction, and psychosis, contain indole rings. These substances have a wide range of benefits, including the capability for treating parasites, suppress inflammation, eradicate bacteria, prevent seizures, fight fungus, and fight tumors. This study focused on the indole moiety and the ongoing investigations into its potential functions. An antiviral drug called arbidol is frequently prescribed to treat influenza. The structure of this compound is fascinating because it has various substituents that are essential for preventing viral entry and boosting the immune system. A compound known as mitraphylline, found in Mitragyna speciosa leaves, has shown promise as a potential cancer treatment. Roxindole was first prescribed to treat schizophrenia, but it also has strong anxiolytic and antidepressant properties, along with a low degree of antipsychotic efficacy.

کلیدواژه ها:

HIV ، cancer ، Psychosis ، tumours ، seizures ، etc