Investigating the Role of BRCA۲ Gene in Predicting Prostate Cancer Progression in Tehran Hospitals in ۲۰۲۱-۲۰۲۴

Introduction: Prostate cancer is one of the most common cancers in men, and genetic mutations in various genes play a significant role in its progression. The BRCA۲ gene, a tumor suppressor gene, is associated with an increased risk of prostate cancer. The aim of this study is to investigate the role of BRCA۲ mutations in predicting prostate cancer progression in Iranian patients. Methods: This study included ۲۵۰ prostate cancer patients treated in Tehran hospitals between ۲۰۲۰ and ۲۰۲۳. We used polymerase chain reaction (PCR) to detect BRCA۲ mutations and DNA sequencing to confirm them. Results: The results showed that ۱۸% of patients had a BRCA۲ mutation associated with an older mean age at diagnosis, higher metastasis rate on MRI imaging, and shorter survival. Also, mutations in the aforementioned gene are associated with specific clinical features and more aggressive progression of prostate cancer.Conclusion: The integration of genetic testing and imaging provides valuable tools for the prediction and management of prostate cancer, especially in Iranian patients.

کلیدواژه ها:

MRI ، prostate ، cancer ، BRCA۲ Gene