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مقالات فارسیISIکنفرانسهاژورنالها

Extracts of Apium graveolens (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf۲-antioxidant signaling pathways

محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 15، شماره: 4
سال انتشار: 1404
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 17

فایل این مقاله در 17 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/2290663

شناسه ملی سند علمی:

JR_AJP-15-4_007

تاریخ نمایه سازی: 2 تیر 1404

چکیده مقاله:

Objective: This study aimed at investigating the protective effect of extracts from Apium graveolens against gentamicin-induced hepato-renal toxicity.Materials and Methods: The aqueous and hydro-ethanolic extracts of A. graveolens designated respectively as WAG and HAG were tested for their in vitro antioxidant activities. Then, their cytoprotective effects were assessed against gentamicin-induced cytotoxicity in primary mouse hepatocytes. Finally, mice were administered with gentamicin (۲۰ mg/kg) and co-treated with HAG for ۱۴ days, and histopathology, biochemical and molecular parameters related to gentamicin-induced toxicity were evaluated.Results: HAG exhibited outstanding chemical antioxidant activities and preserved hepatocytes from gentamicin-induced cytotoxicity.  HAG relieved liver and kidney histopathological and biochemical changes, and enhanced the mRNA level of Nrf۲ and its target gene HO-۱ in gentamicin-intoxicated mice.Conclusion: HAG attenuates hepato-renal injuries induced by ۱۴-days administration of gentamicin in mice through the activation of Nrf۲-antioxidant signaling pathways.

کلیدواژه ها:

Apium Graveolens ، Gentamicin-toxicity ، Mice ، Liver ، Kidney ، protection ، Antioxidant

نویسندگان

Arnaud Kouam

Medical Research and Applied Biochemistry Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Mayelle Mokam

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Eleonore Ngounou

Anatomy Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Ferdinand Kouoh

Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé ۱, P.O. Box ۸۱۲, Yaounde ۱, Cameroon

Rodrigue Fifen

Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé ۱, PO Box ۸۱۲, Yaoundé, Cameroon

Kerinyuy Kongnyuy

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Elisabeth Zeuko’o

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Nembu Nembo

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon

Pascal Dieudonné Djamen

Higher Institute of Health Sciences, Université des Montagnes, P.O. Box ۲۰۸, Bangangté, Cameroon

Frédéric Njayou

Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé ۱, P.O. Box ۸۱۲, Yaounde ۱, Cameroon

Paul Moundipa

Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of Science, University of Yaoundé ۱, P.O. Box ۸۱۲, Yaounde ۱, Cameroon

Emmanuel Asongalem

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box ۶۳, Buea, Cameroon