CNTs-COOH Paste Electrode for Detection of Temozolomide

The MWCNTs-COOH Paste Electrode (MCPE) was successfully used to study the electrochemical behavior of temozolomide in ۰.۲ M H۲SO۴ solution, phosphate buffer solution (۰.۱M PBS, pH ۷.۴) and ۰.۱M NaOH solution by Cyclic Voltammetry (CV) technique. The results exhibit that MCPE can remarkably enhance sensing and electrocatalytic activity towards the oxidation and reduction of temozolomide in acidic, neutral, and basic solutions. The effect of the scan rate exhibits the adsorption controlling process. The effect of pH range from ۲ to ۶ was investigated by cyclic voltammetry technique, from cyclic voltammetry study exhibits the peak current was pH-dependent with a slope of ۶۸ mV/pH.  The detection limit (LOD)) at MCPE were found to be ۰.۰۵۶ mM,۰.۰۶۹ mM and ۰.۰۶۵ mM in ۰.۱M H۲SO۴, ۰.۱M PBS (pH ۷.۴)  and ۰.۱M NaOH solutions  respectively by Cyclic Voltammetric (CV) technique. Similarly, from Linear Scan Voltammetric (LSV) technique, the detection limits (LOD) were found to be ۰.۰۵۰ mM, ۰.۰۲۱mM and ۰.۰۳۶ mM in acidic, neutral, and basic solution respectively. The proposed method was successfully applied for the determination of temozolomide in the clinical sample.

کلیدواژه ها:

Temozolomide ، MWCNTs-COOH ، MWCNTs-COOH paste electrode ، Cyclic Voltammetry and Linear scan voltammetry