An Experimental and Theoretical Study on Bicyclo-۳,۴-Dihydropyrimidinone Derivative: Synthesis and DFT Calculation

We report here an efficient and green method for fused Biginelli condensation reaction of aldehydes, cyclopentanone, and urea catalyzed by nano ZrO۲-SO۳H under solvent-free conditions. The prospect of the reusability of this catalyst has also been demonstrated without compromising on the yield of the product. On the whole, the protocol presented here is an excellent alternative to many of the previously reported procedures. So, Optimized molecular structures have been investigated by DFT/B۳LYP method with ۶-۳۱G (d,p) basis set. Stability of some ۴-aryl-۷-benzylidene-۱,۳,۴,۵,۶,۷-hexahydro-۴-phenyl-۲H-cyclopenta[d]pyrimidin-۲-one (۲ a-j) derivatives and intramolecular interactions bond has been analyzed by using natural bond orbital (NBO) analysis.

کلیدواژه ها:

Fused Biginelli condensation reaction ، ۴-aryl-۷-benzylidene-۱ ، ۳ ، ۴ ، ۵ ، ۶ ، ۷-hexahydro-۴-phenyl-۲H-cyclopenta[d]pyrimidin-۲-one ، DFT/B۳LYP ، NBO