Molecular Dynamics, Biological Study and Extractive Spectrophotometric Determination of Vanadium (V) - ۲-methyl-۸-quinolinol Complex

An extractive spectrophotometric method is developed for the trace determination of vanadium (V). ۲-Methyl-۸-quinolinol(MQ) reacts with vanadium(V) to form a ۱:۲ (V : MQ) light brown complex in an aqueous medium at ۰.۰۵ M CH۳COOH concentration which is quantitatively extractable into chloroform exhibiting maximum absorbance in the range ۳۹۷- ۴۰۵ nm. The complex is synthesized in ۱:۲ ratio and the structure of the formed complex is elucidated on the basis of IR, NMR, and TGA techniques aided with computational studies. The formed V (V)-MQ complex is also screened for its in vitro antimicrobial activity. The method obeys Beer’s law up to ۶.۲ µg V/mL with molar absorptivity and  Sandell’s sensitivity of ۲.۴۴۹ × ۱۰۳ L/mol.cm and ۰.۰۲۰۸ µg V/cm۲, respectively, at ۴۰۰ nm. The method is simple, rapid, and has good reproducibility with a standard deviation of ± ۰.۰۰۲۷ absorbance units.

کلیدواژه ها:

Vanadium (V) ، ۲-methyl-۸-quinolinol ، Extraction ، Spectrophotometric Determination ، structural elucidation ، Antimicrobial activity