Synthesis, Molecular Docking and Anticancer Activity of Novel (E)-۵-((۱-phenyl-۱H-۱,۲,۳-triazol-۴-YL)Methylene)-۲-thioxothiazolidin-۴-one Analogues

A novel series of (E)-۵-((۱-Phenyl-۱H-۱,۲,۳-triazol-۴-yl)methylene)-۲-thioxothiazolidin-۴-one analogues were designed for anticancer activity and synthesized by the reaction of ۱-Aryl-۱H-۱,۲,۳-triazole-۴-carbaldehydes with ۲-thioxothiazolidin-۴-one. The synthesized compounds were analyzed by IR, ۱HNMR, ۱۳CNMR, and mass spectrometry. The compounds were screened for in vitro anticancer activity using four cancer cell lines viz. Lung (A۵۴۹), Colon (HT-۲۹), Breast (MCF-۷), and Melanoma (A۳۷۵), resulted from most of the compounds showed moderate to better activity against all cell lines, among them the compounds ۶g and ۶j were the most potent in all investigated cancer cell lines (lung, colon, breast, and melanoma. The compounds were studied in molecular docking studies, which resulted in a significant dock score shown with all the compounds. The compounds ۶i and ۶b have shown the highest dock scores.

کلیدواژه ها:

Anticancer activity ، ۲-Tioxhothiazolidin-۴-one ، ۱ ، ۲ ، ۳-triazole ، Molecular docking studies