NaHSO۴-SiO۲: An Efficient Reusable Green Catalyst for Selective C-۳ Propargylation of Indoles with Tertiary Propargylic Alcohols

Although several methods for the preparation of ۴o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of ۳o propargyl alcohols to form allenium intermediates in acidic media.  It is therefore a challenge to find an efficient method for the C-۳ propargylation of indoles with ۳° propargylic alcohols.  In this paper we wish to report on the successful application of silica gel impregnated with NaHSO۴ as catalyst for the preparation of ۴o propargyl indole derivatives.

کلیدواژه ها:

Alkylation ، catalyst ، Indole ، Propargylic alcohols ، Sodium bisulfate-silica