Novel Cyclic Schiff Base and Its Transition Metal Complexes: Synthesis, Spectral and Biological Investigations

۲, ۵-hexanedione,۳,۴-diacetyl, and ethylenediamine were condensed to obtain a novel Schiff base ligand. Ni(II) and Co(II) complexes have been synthesized by reacting ligand with metal salts in a ۱:۱۰ ratio.  Elemental analysis, IR, ۱HNMR, and mass spectrometry revealed a unique structure, a cyclic decamer, of ligand and metal complexes. Synthesized compounds were screened for anti-microbial character against fungi viz. Aspergillus niger and Trichophyton rubrum and bacteria viz. Staphylococcus aureus and Klebsiella pneumonia, using well plate diffusion method. Investigation of antiangiogenic activity was done using CAM assay. Biological activities of ligand were found enhanced after coordination with metal ions.

کلیدواژه ها:

۲ ، ۵-hexanedione ، ۳ ، ۴-diacetyl ، Schiff Base ، antiangiogenic activity ، anti-microbial study