Preparation, In-Vitro Evaluation, and Delivery of Colchicine via Polyacrylamide Hydrogel

Hydrogels have excellent biocompatibility and are widely used in biomedical applications. However, it is still a challenge to build a hydrogel with outstanding mechanical properties and multiple functions. In this study, a polyacrylamide (PAM) hydrogel with a uniform network structure was achieved through an UltraViolet (UV)-responsive organic crosslinking agent and a higher mechanical strength PAM-Ag+ hydrogel was designed through the introduction of silver ion by metal coordination interaction. Various contents of N'N-bis(acryloyl)cysteamine (BACA)  as cross-linker, acrylamide (AM) as a monomer, and Irgacure ۲۹۵۹ as initiator were investigated to have an optimal combination of high strength. Thus, the PAM-Ag+ hydrogel exhibited excellent adhesive behavior that could be fixed to the human forearm and any part of the skin, such as the finger and elbow joint. In addition, the properties and biocompatibility evaluations of the tough hydrogel in medical wound dressing were investigated. Meanwhile, these results showed that PAM-Ag+ hydrogels possess high stretchable (۲۶۰۰%) and mechanical robust (۲.۵۵ MPa) properties. Excitingly, the release of colchicine (Col) of more than ۹۵% in ۴۸ h demonstrated the hydrogel's high potential in medical dressing and drug release applications by virtue of the excellent moisture retention, permeability, water tightness, swelling ratio, and biocompatibility.

کلیدواژه ها:

hydrogels ، high mechanical strength ، medical dressing ، Drug release