Synthesis and Biological Activity of a New Pt(II) Complex Involving ۴-bromo-۲,۶-bis-hydroxymethyl-phenol and Nicotinamide

IIn the present study, a Pt(II) complex including ۴-Bromo-۲,۶-bis-hydroxymethyl-phenol (BBHMP) and nicotinamide (NA) was synthesized and structurally analyzed by using spectral and thermal analysis methods. BBHMP and its Pt(II) complex in the presence of BBHMP and NA were investigated for their antimicrobial, cytotoxicity, gene expression, and antioxidant properties. The antimicrobial activity results showed that the platinum complex displayed a significant effect against Staphylococcus aureus and Candida albicans. The cytotoxicity of BBHMP and platinum complex were determined against human prostate adenocarcinoma (DU۱۴۵) and breast (MCF۷) cancer cell lines by applying the MTT assay. Cytotoxicity results suggested that the Pt(II) complex exhibited moderate cytotoxicity against the growth of these cancer cell lines when compared with the reference drug cisplatin is more effective than free BBHMP and NA. Gene expression results proved that the Pt(II) complex is a special bioactive chemical constituent and potential anticancer agent. The results obtained showed that the complex had highly inhibitory effects on gene expression. In addition, Pt(II) complex also displayed effective antioxidant activity.

کلیدواژه ها:

Platinum(II) ، Bioactive compounds ، Structural analysis ، Bioactivity