Synthesis and in Silico Studies of Novel Potent Kinase Inhibitors: ۳-Indoloylquinoline Alkaloid

An exclusive approach towards the synthesis of indoylquinoline alkaloids has been illustrated, the present article describes the synthesis, in Platelet-derived growth factor receptor and silico molecular docking studies of a new compound ۳-indolylquinoline-۲,۴-diol ۴. The synthesis of ۴ is initiated by a new, efficient, and solvent-free via a thermal Claisen condensation. The structures of the compounds are established using both spectral and analytical data. An in-silico PASS, Swiss ADME-assisted docking approach is found to be suitable for deriving and synthesizing effective receptor tyrosine kinase agents. Claisen ester condensation reaction resulted in the discovery of inexpensive and user-friendly solvents. Structures of the newly synthesized compounds were characterized by FT-IR, ۱H NMR, ۱۳C NMR, and HRMS (FTMS+PESI) analyses.

کلیدواژه ها:

Claisen condensation ، Indol-۳-aceticacid ، ۳-(۱H-indol-۳-yl)quinoline-۲ ، ۴-diol ، Indole-۳-methylacetate ، Molecular Docking ، Protein kinase inhibitors