Synthesis of Functionalized Polyethylene Glycol Coated Metallic Nanoparticles and Their Antimicrobial Application

The present study emphasizes the synthesis of novel polyethylene glycol (PEG) coated metal oxide NanoParticles (NPs) and NanoComposite (NCs). The co-precipitation method was adopted for the synthesis of Fe۳O۴, Fe-Ni, and Fe-Cu in the presence of PEG. The nanoparticles were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infra-Red (FT-IR), and X-Ray Diffraction (XRD) techniques. The FT-IR studies proved that PEG with Fe۳O۴ nanoparticles as well as Fe-Ni and Fe-Cu nanocomposite were bonded together. The average particle sizes of Fe۳O۴-PEG, Fe-Ni-PEG, and Fe-Cu-PEG nanocomposites were found less than ۱۰۰nm precisely to be ۷۵.۵, ۸۲.۸, and ۷۰.۲nm respectively as determined by SEM and XRD analyses. Moreover, their functionality for antimicrobial activity against pathogenic microbes including P.aeruginose, Proteus miribilis, Klebsiellatyphi, Staphylococcus aureus, and Saccharomyces cerevisiae was examined. The Fe-Cu-PEG and Fe-Ni-PEGNCs have stronger antibacterial activity compared to Fe۳O۴-PEG. This study would be helpful for the treatment of bacterial and viral diseases.

کلیدواژه ها:

Antimicrobial activity ، Coating ، Nanocomposite ، nanoparticles ، Pathogenic microbes ، Polyethylene glycol (PEG)