The Effect of Process Variables on the Properties of Ketoprofen Loaded Solid Lipid Nanoparticles of Beeswax and Carnauba Wax

Solid Lipid Nanoparticles (SLNs) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. This manuscript describes the effect of process variables on the production of Solid Lipid Nanoparticles (SLNs) from beeswax and carnauba wax and ketoprofen release from these carriers. It was found that by increasing drug content from ۰.۵ to ۱.۵% w/v the average particle size of SLNs increased from ۸۲ to ۱۱۶ nm and drug loading increased from ۱۰.۷ to ۲۶.۶% while entrapment efficiency remained almost constant (≈ ۹۷%). Unexpectedly, the average size of SLNs increased from ۸۲ to ۱۵۰ nm by increasing homogenization time from ۵ to ۱۵ min. Increasing homogenization intensity from ۱۱۰۰۰ to ۲۴۰۰۰ rpm resulted in the particle size decrease from ۱۰۸ to ۸۲ nm. The rate of drug release from nanparticles loaded with ۰.۵% w/v ketoprofen increased with increasing the ionic concentration of phosphate buffer solution from ۰.۰۵ to ۰.۱ M.

کلیدواژه ها:

Solid lipid nanoparticles ، Ketoprofen ، Beeswax ، Carnauba wax ، Sustained release