A Simple and Efficient Procedure Toward ۲-Thioxoquinazolin-۴(۱H)-One Derivatives

A facile synthetic route for constructing ۲-thioxoquinazolin-۴(۱H)-one derivative through cyclization reactions using readily available starting materials ۲-aminobenzoic acids, alkyl/aryl amines, and carbon disulfide is described. These reactions occur under mild conditions, producing the desired products with good to high yields. Molecular docking was conducted to assess the activities of the ۲-thioxoquinazolin-۴(۱H)-one derivative against breast cancer protein (PDB ID: ۱JNX), liver cancer protein (PDB ID: ۲H۸۰), and colon cancer protein (PDB ID: ۴UYA). Furthermore, an ADME/T analysis was performed to evaluate the impact of these compounds on human metabolism.

کلیدواژه ها:

۲-Thioxoquinazolin-۴(۱H)-one Derivative ، Cyclization reaction ، Molecular Docking ، Breast cancer ، liver cancer ، ADME/T