Analgesic, Antipyretic, and Anti-Spasmodic Activities of Solvent Fractions Derived from Chenopodium Ficifolium on Albino Mice

Albino mice, hot plat-induced spasm, charcoal-induced spasm, and brewer yeast-induced pyrexia were used to assess the analgesic, anti-spasmodic, and antipyretic activities.The experimental groups received doses of ۱۰۰ and ۲۰۰ mg/kg of chloroform, n-hexane, ethyl acetate, and aqueous fractions. The n-hexane fraction at a dosage of ۲۰۰ mg/kg notably prolonged the reaction time (P<۰.۰۱) and mitigated paw edema only at the ۲۰۰ mg/kg level across all models. Significant suppression of rectal temperature was noted with a higher dosage (۲۰۰ mg/kg) of chloroform friction. Analgesic activity was prominently exhibited by the ethyl acetate fraction, yielding results on par with the established standards. These findings underscore the promise of these fractions in mitigating pain-associated reactions, Brewer's yeast-induced hyperthermia, and charcoal-induced spasms. Enhanced efficacy was evident at dosages of ۱۰۰ mg/kg and ۲۰۰ mg/kg of the organic fraction obtained from Chenopodium ficifolium, particularly in the management of fever, pain, and spasmodic conditions.

کلیدواژه ها:

analgesia ، pyrexia ، spasmodic ، C. ficifolium ، albino mice