Determination of Acid Dissociation Constants of Some ۲-(۳H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry

The acid dissociation constant values of some ۲-(۳H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method. These compounds have benzoxazolone core structures with arylpiperazine substituents and have been investigated for their anti-inflammatory and analgesic activities. The ۲-(۳H)-benzoxazolone derivatives showed acid dissociation constant values ranging from ۸.۲۶ to ۹.۲۸. The ۵-chloro-۲-(۳H)-benzoxazolone derivatives exhibit higher acidity than the ۲-(۳H)-benzoxazolone derivatives. Additionally, a comparison of  ۵-chloro-۲-(۳H)-benzoxazolone derivatives showed that derivatives with halogen-containing R۲ groups exhibited higher acidity. The findings of this study also suggest that UV–Vis spectrophotometry is one of the most effective techniques for measuring acid dissociation constant values.

کلیدواژه ها:

Benzoxazolone ، NSAIDs ، pKa ، Dissociation Constant ، UV-Vis spectrophotometry