The Effect of Estrogen Hormone on Wound Healing

Post-menopausal women have an increased risk of developing a number of degenerative pathological conditions, linked by the common theme of excessive inflammation. Systemic estrogen replacement (in the form of hormone replacement therapy) is able to accelerate healing of acute cutaneous wounds in elderly females, linked to its potent anti-inflammatory activity. Estrogen protects against the development of chronic non-healing wounds. Estrogen is a key pleiotropic agent Beneficial effect on a range of skin cell types involved in various aspects of wound healing including inflammation, re-epithelialization, angiogenesis, matrix deposition and wound regeneration. Indeed, at the level of gene expression, estrogen is more important than intrinsic aging in the ontogeny of pathological repair. Understanding the role of estrogen on the skin may provide further opportunities for the development of estrogen-related therapy to aid in wound healing.

کلیدواژه ها:

degenerative ، estrogen ، estrogen receptor ، wound healing ، pleiotropic