Antibacterial Efficacy of Metal-Phenolic Networks: Novel Solution for Wound Care

Antibacterial metal-phenolic networks (MPNs) have emerged as a promising innovation in the field of wound care, combining natural polyphenols and multivalent metal ions to address the challenges posed by chronic wounds. Chronic wounds often suffer from bacterial infections, delayed healing, and persistent inflammation, leading to significant morbidity and increased healthcare costs. Traditional treatment options frequently encounter issues such as bacterial resistance and adverse effects, signaling the need for advanced therapeutic materials. MPNs represent a novel approach by synergistically integrating the antimicrobial properties of metal ions with the healing-promoting attributes of polyphenols. MPNs are formed through the coordination of multivalent metal ions such as silver, zinc, and copper with polyphenolic compounds, primarily sourced from natural plants. These networks possess unique structural properties, allowing for versatile applications such as hydrogels, coatings, and nanoparticles. The intrinsic properties of MPNs facilitate the controlled release of metal ions, leading to sustained antibacterial activity targeting a broad spectrum of pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. The antibacterial mechanisms of MPNs are multifaceted. Metal ions disrupt bacterial cell membranes, generate reactive oxygen species (ROS), and modulate inflammatory responses. Dependent on the metal ion concentration and the type of polyphenol, these materials can weaken the biofilms formed by bacteria, further enhancing their therapeutic efficiency. In addition, interaction between MPNs and biological tissues promotes wound healing through antioxidante effects and modulation of inflammation. Polyphenols in MPNs have demonstrated the ability to scavenge excess ROS and promote the activation of healing-associated macrophages, thereby improving the wound microenvironment and fostering tissue regeneration. Fabrication of MPNs typically involves straightforward methodologies, such as 'one-step' or 'multi-step' assembly processes, enabling scalability and adaptability for clinical applications. Flexibility in design allows optimization of physical characteristics including porosity, mechanical strength, and drug delivery capabilities. Recent advances in nanotechnology have further enhanced the performance of MPNs, positioning them as multifunctional materials capable of integrating various therapeutic modalities, such as photothermal therapy, chemodynamic therapy, and anti-inflammatory treatments. In vivo studies have validated the biocompatibility and safety of MPNs, revealing significant improvements in wound closure rates compared to traditional dressings. The presence of bioactive components facilitates the optimal healing pathway, reduces scar formation, and improves overall patient outcomes. Furthermore, ongoing research aims to elucidate the optimal combinations of metal ions and polyphenols to maximize synergistic effects and minimize cytotoxicity.

کلیدواژه ها:

Antibacterial ، Metal-Phenolic Networks ، Wound Care ، Chronic Wounds ، Polyphenols ، Metal Ions ، Antimicrobial ، Biofilms ، Nanotechnology ، Therapeutic Materials