Innovative Approaches for Stabilizing Recombinant Growth Factors in Diabetic Foot Ulcer Treatment

Diabetic foot ulcers are a common and serious complication in diabetic patients, significantly impacting their quality of life and requiring effective treatment strategies for healing. In this context, recombinant growth factors have emerged as potential tools to accelerate the wound healing process. This review examines various methods for stabilizing growth factors, including biocarriers, nanoparticles, and microencapsulation techniques. Biocarriers, such as hydrogels and natural polymers, have garnered significant attention for their ability to maintain moisture and provide a conducive environment for wound healing. Incorporating growth factors into these carriers can facilitate a controlled and sustained release, thereby enhancing the healing process. Nanoparticles, due to their small size and unique properties, can effectively deliver growth factors to target cells, reducing their degradation in the wound environment. Furthermore, nanoparticles may possess antimicrobial properties, which are crucial in preventing infections in diabetic wounds. Microencapsulation techniques create protective layers around growth factors, preventing their degradation in adverse conditions and providing better control over their release. These approaches can significantly improve the healing process of diabetic foot ulcers and reduce associated complications. In conclusion, this review suggests that combining these methods could lead to the development of smarter and more effective wound dressings, enhancing the health outcomes of diabetic patients.

کلیدواژه ها:

Recombinant Growth Factors ، Recombinant DNA Technology ، Wound Healing ، Diabetic Foot Ulcers