Gene-activated Matrices (GAMs) in Regeneration of Wound Healing

Gene-activated matrices (GAMs) represent an cutting edge advancement in regenerative medicine, combining gene therapy with tissue engineering to improve wound healing and tissue regeneration. This approach focuses to restore the structure and function of damaged tissues by transporting therapeutic genes directly to the position of injury, offering a promising solution for different types of wounds, containing chronic and acute injuries. GAMs function through several key mechanisms including: DNA Incorporation by Therapeutic plasmid DNA which integrated into a scaffold made from biocompatible materials like hydrogels or sponges, Sustained Release of DNA in controlled manner maintaining a localized concentration of therapeutic genes within the wound environment, gene expression of essential growth factor for tissue repair and regeneration and promoting of proliferation, migration and differentiation.

کلیدواژه ها:

Gene-activated matrices ، GAMs ، regenerative medicine ، gene therapy ، tissue engineering ، wound healing ، tissue regeneration